abstract：:Five patients with clinically overt myocarditis in the setting of systemic lupus erythematosus were analyzed in terms of associated clinical and serologic features. Myositis and antibodies to nuclear ribonucleoprotein (RNP) were present in all. A retrospective review in 140 consecutive patients with systemic lupus ery...

journal_title：Annals of internal medicine

authors： Borenstein DG,Fye WB,Arnett FC,Stevens MB

更新日期：1978-11-01 00:00:00

abstract：:We studied the clinical and laboratory characteristics of 71 patients with hairy cell leukemia to ascertain whether prognostic factors important for the therapy of the disease existed. Granulocytopenia of less than 500/mu 1 was associated with the occurrence of a serious infection in 46% of the patients, compared to 1...

journal_title：Annals of internal medicine

authors： Golomb HM,Catovsky D,Golde DW

更新日期：1978-11-01 00:00:00

abstract：:Medical devices have become an integral part of hospital-based care but also predispose patients to more than 850 000 device-related infections annually. Devices predispose to infection by damaging or invading epithelial and mucosal barriers to infection, by supporting growth of microorganisms and thus serving as rese...

journal_title：Annals of internal medicine

authors： Stamm WE

更新日期：1978-11-01 00:00:00

abstract：:Several trends in medical education affect our supply of future physicians. The number of new physicians has increased so that each year there is an excess of about 6000 over the number of physicians produced per year a decade ago. Increasing numbers of women and members of minority groups are entering the profession ...

journal_title：Annals of internal medicine

authors： Cooper JA

更新日期：1978-11-01 00:00:00

abstract：:Clinical features of 99 patients with staphylococcal infection were reviewed, and sera were tested by solid-phase radioimmunoassay and gel diffusion for staphylococcal antibodies to ascertain whether these variables predict the extent of infection and the need for prolonged therapy. Clinical features, including the pr...

journal_title：Annals of internal medicine

authors： Wheat LJ,Kohler RB,White A

更新日期：1978-10-01 00:00:00

abstract：:A patient with a retained bullet developed lead poisoning in association with thyrotoxicosis. The clinical and laboratory data suggest that lead was mobilized from an increased mobile bone pool during the hypermetabolic period with resultant poisoning. The findings give factual support to earlier concepts that lead po...

journal_title：Annals of internal medicine

authors： Cagin CR,Diloy-Puray M,Westerman MP

更新日期：1978-10-01 00:00:00

abstract：:Many investigations consider the presence of e antigen (HBeAg) valuable in predicting which patients with acute hepatitis B are at risk of remaining infected and developing chronic liver disease. We tested this hypothesis in a retrospective study of serial samples from patients undergoing long-term hemodialysis. We fo...

journal_title：Annals of internal medicine

authors： Werner BG,Blumberg BS

更新日期：1978-09-01 00:00:00

abstract：:We have seen two patients whose hepatitis was due to the administration of aprindine, a new antiarrhythmic agent. In both patients evidence of hepatitis appeared within 3 weeks of initiating aprindine therapy and resolved rapidly when the drug was withdrawn. The reintroduction of aprindine in one patient was associate...

journal_title：Annals of internal medicine

authors： Herlong HF,Reid PR,Boitnott JK,Maddrey WC

更新日期：1978-09-01 00:00:00

abstract：:Antibody to native DNA was measured by five techniques: the Crithidia luciliae immunofluorescence (CL-IF) test; filter radioimmunoassays using either untreated human KB DNA, endonuclease-treated KB DNA, or a synthetic polynucleotide (poly dAT); and the Farr immunoprecipitation assay using KB DNA. The specificity and s...

journal_title：Annals of internal medicine

authors： Chubick A,Sontheimer RD,Gilliam JN,Ziff M

更新日期：1978-08-01 00:00:00

abstract：:A controlled clinical trial compared three-drug and four-drug combination chemotherapy in 109 patients with advanced small-cell anaplastic carcinoma of the lung. The combination of vincristine, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), cyclophosphamide, and methotrexate was significantly superior to the com...

journal_title：Annals of internal medicine

authors： Hansen HH,Dombernowsky P,Hansen M,Hirsch F

更新日期：1978-08-01 00:00:00

abstract：:Disseminated candidiasis has become an important infection, particularly in immunocompromised and postoperative patients. Although serologic tests may, in some settings, facilitate a premortem diagnosis, the disease is usually diagnosed by comprehensive clinical evaluation. Detection of the relatively newly recognized...

journal_title：Annals of internal medicine

authors： Edwards JE Jr,Lehrer RI,Stiehm ER,Fischer TJ,Young LS

更新日期：1978-07-01 00:00:00

abstract：:The relation between blood pressure before stroke and survival after the event, was examined in the Manitoba study cohort of 3983 men. The last recorded blood pressure before the first stroke and the change in blood pressure from a measurement 5 years earlier were used. Increasing magnitude of systolic blood pressure ...

journal_title：Annals of internal medicine

authors： Rabkin SW,Mathewson FA,Tate RB

更新日期：1978-07-01 00:00:00

abstract：:It is hypothesized that peritoneal fluid might be used as an alternative vehicle for monitoring the clinical chemistry of patients on peritoneal dialyses and save these patients the venesection and resultant blood loss. Peritoneal fluid was obtained before 47.2% of 106 dialysis treatments and compared with simultaneou...

journal_title：Annals of internal medicine

authors： Kelton JG,Ulan R,Stiller C,Holmes E

更新日期：1978-07-01 00:00:00

abstract：:Forty patients with systemic lupus erythematosus randomly received inactivated bivalent (A/NJ and A/Victoria) influenza vaccine or saline in a double-blind study. During 20 weeks of follow-up, no deterioration in major organ function or increase in disease flares was observed in the immunized group as compared with th...

journal_title：Annals of internal medicine

authors： Williams GW,Steinberg AD,Reinertsen JL,Klassen LW,Decker JL,Dolin R

更新日期：1978-06-01 00:00:00

abstract：:Two kindreds affected by maturity-onset type of hyperglycemia in young people were studied. The postglucose-load hyperglycemia segregated as an autosomal dominant trait; it was always mild, never requiring insulin, and generally seemed to start in the first two decades of life. Glucose, insulin, glucagon, and growth h...

journal_title：Annals of internal medicine

authors： Barbosa J,Ramsay R,Goetz FC

更新日期：1978-05-01 00:00:00

abstract：:Dietary deficiency of vitamin B-12 has been reported, yet most people ingesting vitamin-B12-deficient diets even for many years appear to achieve a balance that does not lead to overt signs and symptoms of deficiency. I present the case of a vegan of 25 years' duration who developed severe neurologic abnormalities due...

journal_title：Annals of internal medicine

authors： Carmel R

更新日期：1978-05-01 00:00:00

abstract：:The management of asymptomatic hyperuricemia is controversial. Reported benefits from treatment prevention of acute gouty arthritis, chronic tophaceous gout, urolithiasis, or gouty nephropathy. A review of experimental and clinical data suggests that the risks of asymptomatic hyperuricemia are small or unknown and the...

journal_title：Annals of internal medicine

authors： Liang MH,Fries JF

更新日期：1978-05-01 00:00:00

abstract：:Between September 1972 and January 1976 an outbreak of dialysis dementia affected 20 patients maintained by long-term hemodialysis. The clinical picture was characterized by an insidious onset of altered behaviour, dementia, speech disturbance, myoclonus, and convulsions. Nineteen patients died, but one patient has su...

journal_title：Annals of internal medicine

authors： Dunea G,Mahurkar SD,Mamdani B,Smith EC

更新日期：1978-04-01 00:00:00

abstract：:Twenty-one juvenile-onset diabetic patients with azotemic nephropathy underwent coronary angiography and left ventriculography before renal transplantation or chronic hemodialysis. Two-year survival of 12 patients with no coronary artery disease (group A) was 88% compared to 22% for nine patients with coronary artery ...

journal_title：Annals of internal medicine

authors： Weinrauch LA,D'elia JA,Healy RW,Gleason RE,Takacs FJ,Libertino JA,Leland OS

更新日期：1978-03-01 00:00:00

abstract：:During 1973 and 1974, we looked for cases of Colorado tick fever throughout Colorado; 228 cases were identified. Although 90% of the patients reported exposure to ticks before illness, only 52% were aware of an actual tick bite. Typical symptoms of fever, myalgia, and headache were common, but gastrointestinal symptom...

journal_title：Annals of internal medicine

authors： Goodpasture HC,Poland JD,Francy DB,Bowen GS,Horn KA

更新日期：1978-03-01 00:00:00

abstract：:Severe hypocalcemia secondary to magnesium depletion has been described in numerous patients with gastrointestinal disorders. The development of profound hypomagnesemia in chronic renal disease is a rare finding. We studied three patients with advanced renal failure and magnesium depletion. Severe hypocalcemia also wa...

journal_title：Annals of internal medicine

authors： Mennes P,Rosenbaum R,Martin K,Slatopolsky E

更新日期：1978-02-01 00:00:00

abstract：:Subjects (109) with symptomatic Paget's disease of bone were treated with 5, 10, or 20 mg of sodium etidronate (EHDP)/kg body weight - day for 6 to 24 months. Significant decreases in serum alkaline phosphatase and urinary hydroxyproline were noted after 6 months of therapy; no significant further improvement resulted...

journal_title：Annals of internal medicine

authors： Khairi MR,Altman RD,DeRosa GP,Zimmermann J,Schenk RK,Johnston CC

更新日期：1977-12-01 00:00:00

abstract：:The classification of acute leukemia has almost invariably been based on the morphologic diagnosis into two broad categories: acute lymphocytic and acute myeloid leukemia. Despite the wide range of morphologic variation in both groups, strict criteria to define the subgroups have only recently been proposed. The conve...

journal_title：Annals of internal medicine

authors：

更新日期：1977-12-01 00:00:00

abstract：:Folate deficiency is a frequent cause of anemia in alcoholics, but little attention has been paid to its prevention. Folic acid was readily soluble in wines of high ethanol content at concentrations of 10 microgram/ml. Lactobacillus casei folate activity of folic acid added to wines was well maintained during a month'...

journal_title：Annals of internal medicine

authors： Kaunitz JD,Lindenbaum J

更新日期：1977-11-01 00:00:00

abstract：:Because the cholesterol-rich very low density (VLD) lipoproteins of subjects with type III hyperlipoproteinemia are distinctively enriched in apolipoprotein E, a radial immunodiffusion assay for apolipoprotein E in whole plasma was developed. Its diagnostic usefulness was tested in randomly selected (n = 174) and hype...

journal_title：Annals of internal medicine

authors： Kushwaha RS,Hazzard WR,Wahl PW,Hoover JJ

更新日期：1977-11-01 00:00:00

abstract：:Thirty-five consecutive patients with progressive systemic sclerosis were prospectively evaluated for evidence of Sjögren's syndrome. Six of the 35 (17%) were judged to have the disorder. This is a higher prevalence than in most reports, but much lower than that recently reportedly by Alarcón-Segovia and associates (7...

journal_title：Annals of internal medicine

authors： Cipoletti JF,Buckingham RB,Barnes EL,Peel RL,Mahmood K,Cignetti FE,Pierce JM,Rabin BS,Rodnan GP

更新日期：1977-11-01 00:00:00

abstract：:Identical male twins had alveolar cell carcinoma with nearly synchronous onset and similar histopathologic features, both metastatic to the brain. The hypothesis is advanced that there are genes shared by these twins that determine not only the susceptibility of pulmonary cells to malignant transformation but also the...

journal_title：Annals of internal medicine

authors： Joishy SK,Cooper RA,Rowley PT

更新日期：1977-10-01 00:00:00

abstract：:We report the case of a 23-year-old woman who developed severe myalgias in association with mild hepatitis B surface antigen-positive hepatitis. Muscle biopsy showed myriads of microvacuoles filled with neutral lipid. Prednisone therapy was associated with complete clearing of all clinical and laboratory abnormalities...

journal_title：Annals of internal medicine

authors： Patten BM,Shabot JM,Alperin J,Dodson RF

更新日期：1977-10-01 00:00:00

abstract：:The training of physicians for the delivery of primary care is becoming a national priority. The period of residency training is viewed by many as the focal point for educational change to meet this demand. The Residency Program in Social Medicine at Montefiore Hospital and Medical Center was begun in 1970 and offers ...

journal_title：Annals of internal medicine

authors： Boufford JI

更新日期：1977-09-01 00:00:00

abstract：:Electrophysiologic studies were done in 32 patients with aortic stenosis. In 24 patients with intact A-V conduction, A-H intervals ranged from 55 to 145 msec and were prolonged in two. Two had split His bundle potentials. The H-V intervals ranged from 25 to 94 msec and were prolonged in 12. The mean H-V interval was 6...

journal_title：Annals of internal medicine

authors： Dhingra RC,Amat-y-Leon F,Pietras RJ,Wyndham C,Deedwania PC,Wu D,Denes P,Rosen KM

更新日期：1977-09-01 00:00:00

abstract：:Acute severe aortic regurgitation is a relatively unfamiliar, though life-threatening, disease. We review its diverse causes, anatomic faults, and hemodynamic sequelae and set the stage for an understanding of the clinical manifestations in light of their physiologic mechanisms. Clinical information includes the natur...

journal_title：Annals of internal medicine

authors： Morganroth J,Perloff JK,Zeldis SM,Dunkman WB

更新日期：1977-08-01 00:00:00

abstract：:Cystic fibrosis was diagnosed after age 13 in 25 patients. All had an elevated sweat chloride and either a sibling with cystic fibrosis or typical pulmonary infection or digestive symptoms caused by exocrine pancreatic deficiency. Fourteen had long-standing pulmonary or digestive symptoms. In contrast, four of eight p...

journal_title：Annals of internal medicine

authors： Stern RC,Boat TF,Doershuk CF,Tucker AS,Miller RB,Matthews LW

更新日期：1977-08-01 00:00:00

abstract：:Four hundred sixty patients and staff from 15 U.S. dialysis centers were surveyed by the immune adherence hemagglutination technique for antibody to hepatitis A antigen (anti-HA). The age-standardized anti-HA prevalence was 42.9% in patients and 42.1% in staff. These rates are almost identical to those of socioeconomi...

journal_title：Annals of internal medicine

authors： Szmuness W,Dienstag JL,Purcell RH,Prince AM,Stevens CE,Levine RW

更新日期：1977-07-01 00:00:00

abstract：:A patient with familial Mediterranean fever and amyloidosis who received a cadaver renal transplant 6 1/2 years ago was studied to determine the relation of the serum precursor of secondary amyloid (SAA) to the clinical course and to the deposition of amyloid in the transplant. Amyloid fibrils extracted from the patie...

journal_title：Annals of internal medicine

authors： Benson MD,Skinner M,Cohen AS

更新日期：1977-07-01 00:00:00

abstract：:Twenty-three patients with hyperparathyroidism from six families with the multiple endocrine adenomatosis (MEA) I-syndrome were tested by secretin provocation. In nine cases this led to increases in serum gastrin ranging from 298 to 13 300 pg/ml, whereas the maximum rise in gastrin in the other 14 patients was 32 pg/m...

journal_title：Annals of internal medicine

authors： Lamers CB,Buis JT,van Tongeren J

更新日期：1977-06-01 00:00:00

abstract：:Hepatitis is a significant complication of the treatment of hemophilia A with factor VIII concentrates. Chronic liver disease in these patients is infrequently documented in the literature. The results of percutaneous liver biopsy, under the coverage of glycine-precipitated factor VIII, in six patients with hemophilia...

journal_title：Annals of internal medicine

authors： Lesesne HR,Morgan JE,Blatt PM,Webster WP,Roberts HR

更新日期：1977-06-01 00:00:00

abstract：:Breast cancer is the major cancer killer of women in the United States. Recent advances in therapy promise more effective control of this illness. The development of hormone receptor analysis permits us to better understand the mechanisms of action of steroid and peptide hormones and increases the likelihood of using ...

journal_title：Annals of internal medicine

authors：

更新日期：1977-06-01 00:00:00

abstract：:Two patients with profound decrease of alpha1-antitrypsin (PiZZ) presented with severe pannicultis (Weber-Christian disease); one had systemic panniculitis including pancreatitis. Another possible case is quoted from the literature. Although milder forms of panniculitis can have normal Pi phenotypes and alpha1-antitry...

journal_title：Annals of internal medicine

authors： Rubinstein HM,Jaffer AM,Kudrna JC,Lertratanakul Y,Chandrasekhar AJ,Slater D,Schmid FR

更新日期：1977-06-01 00:00:00

abstract：:A discrete evoking factor or presumed pathophysiologic mechanism is not recognized in the majority of patients with chronic urticaria or angioedema. Two cases are reported in which chronic urticaria was the main manifestation of an immune cutaneous vasculitis associated with hypocomplementemia attributable to classic ...

journal_title：Annals of internal medicine

authors： Mathison DA,Arroyave CM,Bhat KN,Hurewitz DS,Marnell DJ

更新日期：1977-05-01 00:00:00

abstract：:The Biblical Book of Job is a wisdom book. Wisdom, in this context, refers to the intellectual discipline taught by the sages of ancient Isreael to provide professionals with a realistic approach to the problems of life. Chapter 30 of the Book of Job is a key-index of ideas that, if followed through the book, disclose...

journal_title：Annals of internal medicine

authors： Kapusta MA,Frank S

更新日期：1977-05-01 00:00:00